It’s pretty much fire-and-forget. Set your lists (or take the defaults), point your router DNS to the Pi-Hole, sorted. That’s the simple version. You’re on HN, you’ll want to fiddle, but if just loaded it with default lists and never updated it, it would still probably serve well for some years.

Once in a great while I’ll disable it for five minutes to look at something (Facebook or the like). But that a few button clicks.