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A dose response curve in an observational study is irrelevant for establishing causation.

There is a dose-response relationship between umbrellas outside and rainfall., but umbrellas do not cause rainfall.

And the SSRI point is tangential: they were approved based on RCT evidence. Observing umbrella use and concluding it causes rainfall, even though we don't know of a reason why umbrella use would cause rainfall, is quite different.



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